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Four compounds, N-(2,3-dimethylphenyl)benzamide, N-(3-trifluoromethylphenyl)benzamide, N-(2,3-dimethylphenyl)cinnamamide and N-(3-trifluoromethylphenyl)cinnamamide, were synthesized and evaluated their activity by the method of the inhibitory effect on the carrageenin-induced rat paw edema, compared with phenylbutazone. All of these exhibited anti-inflammatory activity, and N-(2,3-dimethylphenyl)benzamide exhibited 45.7% edema inhibition vs. control when 100mg/kg of dosage was administered, whereas phenylbutazone, 51.4% for 50mg/kg.
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